HOME	MEBI 534 , Autumn 2007 Biology and Informatics
	Histology: Informatics  Assignment A.  Read the following chapter   Imaging and Structural Informatics, Chapter 9 in 3rd edition of Shortliffe et al (eds), Biomedical Informatics 2006 B. Provide written answers to the following questions, to be turned in prior to the Wed class, as per these instructions. These questions are based on the book chapter. 1. What is the general principle that underlies computed axial tomography (CT)? What are the advantages of CT images over conventional X-ray images? 2. Explain the differences among contrast, spatial, and temporal resolution.  3. Describe  the four standard image processing steps,  and suggest how these might be applied by an image analysis program looking for abnormal cells in a PAP smear. 4. What is the segmentation step in image analysis? Why is it so difficult to perform? Give one example of ways by which current systems avoid the problem of automatic segmentation. Give an example of how knowledge about the problem to be solved (for example, local anatomy) could be used in future systems to aid in automatic segmentation.  5. What is a 3-D brain atlas?  What is the use of a brain atlas?
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