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Gene
Expresson: Informatics
Assignment
A. Read the following articles
Quackenbush2001
Array analysis
Stoeckert2002 Array
databases and standards
B. Provide written answers to the following questions, to be
turned in prior to the Wed class, as per
these instructions.
- What is the normalization step in array
analysis, and why is it necessary?
- What is expression space, what is an
expression vector, and what is the purpose of clustering expression
vectors together in expression space?
- What is a dendrogram, and how is it
generated using cluster analysis?
- Explain the concept of ‘molecular
expression fingerprinting’ and how it might be used to create
personalized treatments for diseases such as cancer.
- Define MGED, MIAME, and MAGE, and
explain how they relate to each other.
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